| Jan. 21, 1860 | Delaware - a Cleveland Columbus & Cincinnati Railroad passenger train derailed. No recorded injuries. - Newspaper |
| Sep. 22, 1867 | Black Lick - a Panhandle Railroad passenger train derailed. Seven passengers were killed and 26 injured. - Newspaper |
| July 27, 1871 | Alum Creek - a Baltimore & Ohio Railroad freight train was derailed by an open switch. The engineer was injured. - Newspaper |
| Oct. 11, 1871 | Columbus Union Station - a Baltimore & Ohio Railroad passenger train collided with a freight train. The passenger train conductor was killed. - Newspaper |
| Jan. 6, 1874 | West of Columbus - a Pittsburg Cincinnati & St. Louis Railroad passenger train was the victum of an attempted wreck - Newspaper |
| Summer, 1878 | Sunbury - Cleveland Mt. Vernon & Columbus Railroad (PRR) bridge collapsed under the weight of a freight train. injuries unknown. - Article - includes photos |
| Feb. 18, 1879 | West of Columbus - a Pittsburg Cincinnati & St. Louis Railroad freight train rear ended a leading freight train. No injured. - Newspaper |
| Dec. 17, 1879 | Columbus - Cleveland Mt. Vernon & Columbus Railroad (PRR) passenger train diverted to roundhouse track. Two crewmen injured. - Newspaper |
| Sep. 3, 1881 | Columbus Union Depot - Beeline freight car pushed into High Street Tunnel. No injuries - Article |
| Sep. 12, 1884 | Columbus Union Depot - Ohio Central Railroad (T&OC) Runaway passenger car. No injuries. - Newspaper |
| Sep. 17, 1886 | West side of Columbus near Gift Street - A Little Miami Railroad (PRR) express passenger train rear ended a standing freight train. One injury. - Newspaper |
| Aug. 29, 1888 | Seven miles west of CUD - CS&C (NYC-Big Four) mixed train derailed. Five injuries. - Newspaper |
| Aug. 16, 1889 | Near Columbus Union Station - a Cincinnati, St Louis and Pittsburg Railroad (PRR) freight train rear ended a standing freight train. One person killed and two injured. - Newspaper |
| Feb. 19, 1891 | Valley Crossing - a Columbus Hocking Valley & Toledo Railroad passenger train struck a moving Scioto Valley Railroad freight train. Three persons were injured. - Newspaper |
| Dec. 5, 1891 | Union Station - a Big Four string of cars struck a streetcar power pole. There were no injures. - Newspaper |
| July 14, 1894 | Olentangy Tower - a Baltimore & Ohio Railroad freight train's pilot struck a crossing rail and derailed. One employee was killed and one injured. - Newspaper - includes drawing |
| Sept. 5, 1894 | On the Big Four's Olentangy River Bridge - a Baltimore & Ohio Railroad passenger train was hit by a runaway cut of coal cars. One person killed and two injured. - Newspaper - includes drawing |
| Mar. 3, 1896 | Galena - a Cleveland Akron & Columbus Railroad freight train derailed. One person injured. - Newspaper |
| May 5, 1897 | Olentangy Tower/HV Cabin - a Hocking Valley freight struck a Panhandle freight. No injuries. - Newspaper - includes drawing |
| May 9, 1898 | Chase Street - a Cleveland Akron & Columbus Railroad excursion train jumped the track. one passenger killed, two crewmen, one employee and at least four passengers injured. - Newspaper |
| June 14, 1898 | Owens - a Hocking Valley freight derailed at a broken switch. one brakeman killed. - Newspaper - includes photos |
| July 31, 1898 | Valley Crossing - a Norfolk & Western freight locomotive exploded. No injuries. - Newspaper |
| July 26, 1899 | Sunbury - Cleveland Akron & Columbus Railroad, two trains collide, brakeman asleep at the switch. no injuries. - Newspaper |
| Oct. 30, 1900 | W Broad Street - A Hocking Valley Railway cut of cars struck a Columbus Railway & Light Co. streetcar. One person died, three persons were injured. - Newspaper |
| Feb. 19, 1902 | Shepards - a Columbus Shawnee & Hocking Railway freight train derailed. The engineer was killed and five other persons were injured. - Newspaper |
| April 21, 1902 | Sunbury - Cleveland Akron & Columbus Railroad, burning trestle collapses under train. No injuries. - Newspaper |
| Oct. 1, 1902 | West Side - a Columbus Railway & Light Co. streetcar struck a PRR freight train crossing West Broad Street. Eight persons were injured. - Newspaper |
| Oct. 20, 1902 | Flint - a Cleveland Cincinnati Chicago & St. Louis Railway (Big Four) passenger train derailed. The engineer was killed and ten employees and passengers were injured. - Newspaper - drawing |
| May 30, 1903 | Front Street - a Cleveland Akron & Columbus Railroad string of runaway freight cars crash into a locomotive. One Hocking Valley employee was injured. - Newspaper |
| July 25, 1903 | Near St. Clair Ave. - a Cleveland Akron & Columbus Railroad passenger train struck an N & W locomotive. Two crewmen and six passsengers were injured. - Newspaper |
| June 25, 1904 | Delaware - a Cleveland Cincinnati Chicago & St. Louis Railway (Big Four) passenger train derailed. Three persons were killed and seven were injured. - Newspaper (includes photo) |
| Oct. 28, 1905 | Galena - a Cleveland Akron & Columbus Railroad freight train derailed. There were no injuries. - Newspaper |
| Feb. 25, 1906 | East of Columbus Union Station - Baltimore & Ohio Railroad run-a-way loaded hopper cars crashed into a PRR freight train. There were no injuries. - Newspaper |
| June 18, 1906 | Windsor Avenue. - a Cleveland Akron & Columbus Railroad passenger train struck a spiked switch. There were no injures. - Newspaper |
| Oct. 21, 1906 | West of Columbus Union Station - Big Four Railroad run-a-way freight car crashed into a Big Four freight train. There were no injuries. - Newspaper |
| May 13, 1907 | Truro - a Toledo & Ohio Central Railroad southbound passenger train derailed by an open switch. two persons killed and eighteen injured. - Newspaper - includes drawing |
| June 18, 1907 | North of Columbus Union Station - a Cleveland Cincinnati Chicago & St. Louis Railway (Big Four) southbound passenger train was derailed by an open switch. One person killed and four injured. - Newspaper - includes photo |
| Oct. 1, 1907 | On Town Street - a Baltimore & Ohio Railroad passenger train struck and demolished a street car. There were no injuries - Newspaper |
| July 13, 1908 | Powell - a Hocking Valley Railroad helper locomotive exploded killing the engineer and fireman. - Newspaper |
| Feb. 26, 1909 | Canal Winchester - a Hocking Valley Railroad Passenger train side-swipped a second passenger train. - Newspaper (Photos included) |
| Aug. 18, 1911 | Near Grandview Avenue - a Cleveland Cincinnati Chicago & St. Louis Railway (Big Four) northbound passenger train derailed. Forty-five passengers injured. - Newspaper (includes photo) - ICC Report |
| Aug. 14, 1912 | James Pike Crossing - a Pennsylvania Railroad eastbound mail train struck an automobile. Three automobile passengers killed. - Newspaper |
| Feb. 25, 1913 | Ostrander - a Cleveland Cincinnati Chicago & St. Louis Railway (Big Four) freight train broke an axle. There were no reported injuries. - Article |
| Mar. 2, 1914 | Worthington - a Pennsylvania Railroad southbound passenger train ran into the rear of a freight train. Four trainmen were injured, one fatally. - Newspaper |
| Aug. 12, 1915 | Orient - a Baltimore & Ohio Railroad westbound passenger train was rear ended by a freight train. Six passengers were killed and 32 injured. - Newspaper - ICC Report - includes photos |
| July 3, 1917 | Minerva Park - a Pennsylvania Railroad (CA&C) eastbound freight derailed 12 coal cars. No injuries. - Newspaper |
| Oct. 20, 1918 | PRR/B&O-N&W Crossing - a Baltimore & Ohio Railroad eastbound switching move had a boiler explosion. two crew men were killed. - Newspaper - includes photos |
| Dec. 24, 1919 | Worthington Tower - a Cleveland Cincinnati Chicago & St. Louis Railway (Big Four) northbound freight ran through a derail and overturned. One crew man was killed and two injured. - Newspaper |
| Mar. 6, 1923 | Circleville - a Chesapeake & Ohio freight train derailed and was struck by a passing Norfolk & Western freight train. The N&W engineer was injured. - Newspaper |
| Mar. 30, 1923 | Oakland Park Avenue - a Cleveland, Cincinnati, Chicago, & St. Louis Railway (Big Four) southbound passenger train struck an automobile and was derailed. Eight died and 43 were injured. - Newspaper (includes photo)- ICC Report |
| Dec. 7, 1923 | Near Miami Crossing - a Pennsylvania Railroad eastbound freight train was derailed. One employee was killed and three injured. - Newspaper - ICC Report |
| June 24, 1924 | Linworth - a Hocking Valley Railroad freight train was rear ended by a second freight train. One employee was killed and one was injured. - Newspaper - ICC Report |
| June 23, 1927 | Flint - a Cleveland, Cincinnati, Chicago & St. Louis Railway (Big four) passenger train drive wheel broke. No one was injured. - Newspaper - |
| Aug. 18 1929 | Condit - a Pennsylvania Railroad (CA&C) passenger train derailed. 254 injured. - Newspaper - |
| Oct. 5, 1929 | Columbus Union Station - a Baltimore & Ohio Railroad westbound passenger train locomotive derailed and overurned while leaving the station. There were no injureries. - Newspaper |
| Jan. 28, 1930 | Arnold - a Toledo & Central Ohio Railroad westbound freight train locomotive boiler exploded. Three trainmen were killed. - Newspaper |
| Nov. 16, 1933 | Worthington Tower - a Cleveland, Cincinnati, Chicago & St. Louis Railway (Big four) passenger train derailed because of a broken rail. Thirteen persons injured. - Newspaper - ICC Report - includes photos |
| Dec. 23, 1934 | Paget (Delaware) - a Cleveland, Cincinnati, Chicago & St. Louis Railway (Big four) passenger train crashed into the rear of a mail train. Three employees killed and thirty-two persons injured. - Newspaper - ICC Report - includes photo and drawing |
| Dec. 27, 1934 | Linden (north of Columbus) - a Pennsylvania Railroad (CA&C) passenger train derailed. Three persons were killed and twelve injured. - Newspaper - ICC Report - includes photo, drawing |
| Feb. 7, 1935 | Kile (northwest of Columbus) - a New York Central Railroad freight train buckled. The rear end helper crushed the caboose. Two Crewmen were killed. - ICC Report - includes drawing |
| Jan. 7, 1941 | Miami Crossing - a Pennsylvania Railroad passenger train derailed. One person killed and one injured. - Newspaper (includes photo) - ICC Report |
| Sep. 15, 1941 | Village of San Margherita - a Pennsylvania Railroad freight train derailed due to a broken drawbar. Eleven crude oil tank cars burned. There were no injuries. - Newspaper (includes photo) |
| July 26, 1943 | Pennor Yard Columbus - a Pennsylvania Railroad switch engine, tender and caboose derailed and rolled on to their side. The conductor was injured. - Newspaper (includes photo) |
| Nov. 14, 1943 | James Rd. - a Pennsylvania Railroad passenger train collided with an automobile. Four people were killed and three injured. - Newspaper (includes photo) - ICC Report |
| Mar. 12, 1945 | HV Cabin - a Chesapeake & Ohio Railroad northbound freight train derailed. Three employees were killed. - ICC Report |
| July 2, 1945 | Fourth St. - a Pennsylvania Railroad freight train rear ended another freight train. One employee was killed and one injured. - Newspaper - ICC Report |
| Aug. 26, 1947 | Columbus Union Station - a Pennsylvania Railroad passenger train rear ended a standing PRR passenger train. Six people were injured. - Newspaper |
| June 7, 1948 | Columbus Union Station - a Pennsylvania Railroad passenger train derailed due to an improperly aligned double slip switch. Six people were injured. - Newspaper - (includes photo) - ICC Report - (includes drawing) |
| Mar. 19, 1949 | Roberts Road - a Pennsylvania Railroad freight train derailed. There were no injuries. - Newspaper |
| Apr. 29, 1949 | Newark - a Baltimore & Ohio Railroad passenger train derailed. Seven people were injured. - ICC Report |
| May 5, 1949 | Croton - a New York Central freight train rear ended the local. Three people were injured. - Newspaper - - includes photo |
| July 13, 1949 | Grandview - a Pennsylvania Railroad freight train had six box cars loaded with grain derail near Grandview Avenue. There were no injuries. - Newspaper |
| Nov. 14, 1949 | Plain City - a Pennsylvania Railroad freight train derailed 23 cars near Chillicothe Street. There were no injuries. - Newspaper - (includes photo) |
| Nov. 28, 1950 | Newark - a Pennsylvania Railroad passenger train derailed 1/2 mile west of Route 79. There were no injuries. - Newspaper - (includes photo) |
| May 30, 1951 | Columbus - a New York Central Railroad freight train derailed due to a broken axle. There were no injuries. - Newspaper - (includes photo) |
| Jan. 2, 1952 | Hilliard - a Pennsylvania Railroad freight train derailed and caught fire. Three local firefighters were injured. - Newspaper/Article - (includes photo) |
| Apr. 15, 1955 | Hilliard - a Pennsylvania Railroad freight train derailed. There were no injuries. - Newspaper/Article - (includes photos) |
| Aug. 16, 1957 | Brice - a New York Central Railroad freight train derailed. There were no injuries. - Newspaper - (includes photos) |
| Sep. 23, 1957 | Columbus - a Pennsylvania Railroad J-1 derailed. There were no injuries. - Newspaper/Article - (includes photo) |
| Nov. 30, 1958 | Summit Station - a Pennsylvania Railroad freight train derailed. There were no injuries. - Newspaper |
| Aug. 13, 1959 | US Tower - two Pennsylvania Railroad freight trains collided. Seven trainmen were slightly injured. - Article - includes photos, ICC Report - includes photos, Newspaper |
| Sept. 5, 1962 | Near Nelson Road - a Pennsylvania Railroad switch engine with 75 cars got out of contol and struck two trains. - Three crewmen were injured. - Newspaper - (includes photos) |
| Dec. 18, 1965 | North of Worthington - a New York Central Railroad passenger train struck an earthmover at a rail-highway grade crossing. The driver of the earthmover was killed and 43 persons on the train were injured. - Article - ICC Report - (includes photos) |
| Aug. 4, 1967 | West Jefferson - a Pennsylvania Railroad westbound passenger train derailed. Twenty persons were injured. - Newspaper - ICC Report - (includes photos) |