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The Big Four Train No. 46 is curving north headed for Albany, NY where connections can be made for Boston or New York City. The two tracks on the right and the Yard belong to the Big Four. The two tracks on the left are shared by the Cleveland Akron & Columbus and the Norfolk & Western.
The Fourth Street Bridge is visible through the haze with the Union Station just beyond the bridge. The PRR/B&O four track main is on the far side of the grassy hill. The Stock Yard is behind the camera.
Photo-10 from The Alex Campbell Collection, 1907.